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Some GPCRs can Furniture Carmel online al from endosomes following internalization. Little is known about the localization, aling, and regulation of constitutively active GPCRs. We demonstrate herein that exogenously-expressed GPR3 localizes to the cell membrane and undergoes internalization in HEK cells. To understand which residues are targeted for desensitization, we mutated potential phosphorylation sites in the third intracellular loop and C-terminus and examined the effect on cAMP and receptor surface localization.

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My lab is interested in the regulation of meiosis in mammalian oocytes, as well as the cytoplasmic events that occur during the time an oocyte transitions from an immature cell to a mature egg capable of fertilization.

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